Pitchers Hyun Jin Ryu and Mitch White were placed on Toronto's injured list as the Blue Jays finalized their opening day roster.
Ryu was put on the 15-day IL retroactive to March 27 as he continues to recover from Tommy John surgery he had on June 18.
White was also placed on the 15-day IL retroactive to March 27 with right elbow inflammation.
Toronto began its season on Thursday in St. Louis in the first of a three-game interleague series against the Cardinals.
Ryu made six starts for the Blue Jays last season with a 2-0 record and a 5.67 earned-run average with 16 strikeouts.
The 36-year-old Korean pitcher was pulled from a start against the Chicago White Sox on June 2 shortly after reaching 1,000 career innings pitched and was later diagnosed with damage to his ulnar collateral ligament.
White was projected to be a fifth starter or long-innings reliever for Toronto this season.
The 28-year-old White had a 1-7 record for the Blue Jays last year with a 5.45 ERA over 99 innings pitched with 78 strikeouts.
This report by The Canadian Press was first published March 30, 2023.
The Canadian Press